The four drugs shown below are among the well established and well known examples of what is popularly known as biotherapy or targeted treatment. The table presents the conditions treated, number of clinical trials and patients participating in trials (from clinicaltrials.gov).

They are all monoclonal antibodies that attach to secific receprors on cells.

These drugs are used in a variety of other diseases like rheumatoid arthritis,certain types of colitis and some other autoimmune disorders, where the immune cells of the body are causing problems for the person.

Most frequently they are used in cancer treatment. They are different to standard chemotherapy or cytotoxic treatment, which are regarded as toxic or poisonous to cells ,all cells in general. While the monoclonal antibodies abbreviated as -MAB in the end of the name of the drug are more specific and attach to a particular substance which is more often seen on the cancer cell and hence they are thought to be more specific.

INTERVENING DRUG	Conditions Treated	Clinical Study Sponsored by	Number of Studies	Number of patients enrolled in trials
BEVACIZUMAB	Renal Cell Carcinoma	Industry	4	2012
		NIH	1	22
		Other	5	161
		Other|Industry	3	77
	Pancreatic Cancer	Industry	2	639
		Other	4	191
		Other|Industry	4	151
		Other|NIH	6	256
	Ovarian Cancer	Industry	8	2440
		Other	5	571
		Other|Industry	2	162
	Non-squamous Non-small Cell Lung Cancer	Industry	16	7689
		Other	2	364
		Other|Industry	2	277
	NON-SMALL CELL LUNG CANCER	Industry	22	5306
		Other	4	94
		Other|Industry	10	499
	Metastatic Colorectal Cancer	Industry	6	1129
		Industry|Other	1	142
		Other	27	3342
		Other|Industry	11	1676
	Metastatic Breast Cancer	Industry	8	2866
		Industry|Other	1	600
		Other	3	700
		Other|Industry	5	762
		Other|NIH	1	31
	Lung Cancer	Other	8	585
		Other|Industry	8	473
		Other|NIH	22	2394
	Glioblastoma Multiforme	Industry	9	566
		Other	2	90
		Other|Industry	10	401
		Other|NIH	1	183
	Glioblastoma	Industry	5	1774
		Other	7	258
		Other|Industry	3	127
	Diabetic Macular Edema	NIH|Industry	1	56
		Other	19	1219
		Other|Industry	1	45
		Other|NIH|Industry	1	660
	Colorectal Neoplasms	Industry	6	1224
		Other	6	603
		Other|Industry	2	860
	Colorectal Cancer	Industry	50	18265
		Industry|NIH	1	3451
		Industry|Other	1	194
		NIH	1	0
		Other	19	4076
		Other|Industry	11	826
		Other|NIH	8	601
		Other|NIH|Industry	1	35
	BREAST CANCER	Industry	29	8251
		Industry|Other	1	150
		NIH	1	21
		Other	28	6508
		Other|Industry	33	13102
		Other|NIH	13	2559
CETUXIMAB	Squamous Cell Carcinoma of the Head and Neck	Industry	8	1494
		Other	9	708
		Other|Industry	3	181
	Pancreatic Cancer	Other	10	482
		Other|Industry	2	86
		Other|NIH	6	1014
	NON-SMALL CELL LUNG CANCER	Industry	5	528
		Other	1	601
		Other|Industry	5	224
	Metastatic Colorectal Cancer	Industry	10	3151
		Industry|Other	1	512
		NIH	1	51
		Other	26	4188
		Other|Industry	7	397
		Other|NIH	2	22
	Lung Cancer	Other	1	69
		Other|Industry	2	96
		Other|NIH	7	414
		Other|NIH|Industry	1	109
	Head and Neck Cancer	Industry	8	1632
		NIH	1	46
		Other	21	1312
		Other|Industry	10	313
		Other|NIH	13	2069
		Other|NIH|Industry	1	0
	Esophageal Cancer	Other	7	613
		Other|Industry	1	50
		Other|NIH	4	527
		Other|NIH|Industry	1	245
	Colorectal Cancer Metastatic	Industry|Other	2	494
		Other	6	349
		Other|Industry	6	1533
	Colorectal Cancer	Industry	24	4450
		Other	34	16270
		Other|Industry	11	2309
		Other|NIH	14	711
		Other|NIH|Industry	3	4906
		U.S. Fed|NIH	2	680
HERCEPTIN	BREAST CANCER	Industry	38	14538
		Other	8	547
		Other|Industry	9	450
		Other|NIH	2	2149
		Other|NIH|Industry	1	5
RITUXIMAB	Waldenstrom's Macroglobulinemia	Other	3	422
		Other|Industry	8	262
	Rheumatoid Arthritis	Industry	49	11583
		NIH|Other	1	4
		Other	9	1143
		Other|Industry	3	99
	Non-Hodgkin's Lymphoma	Industry	26	5884
		Industry|Other	2	1511
		Other	9	358
		Other|Industry	8	330
	Mantle Cell Lymphoma	Industry	5	1104
		Other	11	1272
		Other|Industry	7	433
	Lymphoma, Non-Hodgkin	Industry	15	2600
		Other	2	30
		Other|Industry	1	4
	Lymphoma, Follicular	Industry	8	698
		Other|Industry	4	173
	Lymphoma	Industry	13	2505
		Industry|NIH|Other	1	12
		Industry|Other	1	313
		NIH	2	120
		Other	61	10613
		Other|Industry	33	2309
		Other|NIH	75	6091
		Other|NIH|Industry	11	452
	Lymphocytic Leukemia, Chronic	Industry	13	1549
		Industry|Other	3	2361
	Leukemia|Lymphoma	Industry	2	300
		NIH	1	48
		Other	2	79
		Other|Industry	3	200
		Other|NIH	15	746
		Other|NIH|Industry	3	174
	Leukemia	Industry	1	0
		Industry|Other	1	817
		Other	11	712
		Other|Industry	13	1494
		Other|Industry|NIH	1	19
		Other|NIH	9	400
	Follicular Lymphoma	Industry	10	2156
		Industry|Other	1	255
		Other	11	2223
		Other|Industry	7	2263
	Diffuse Large B-Cell Lymphoma	Industry	9	865
		Industry|Other	1	1418
		Other	14	1180
		Other|Industry	8	275
	Diffuse Large B Cell Lymphoma	Industry	2	384
		Other	6	1047
		Other|Industry	4	300
	Chronic Lymphocytic Leukemia	Industry	12	2752
		NIH	1	105
		Other	10	2515
		Other|Industry	20	1623
		Other|NIH	1	31
TRASTUZUMAB	Neoplasms, Breast	Industry	11	1318
		Industry|Other	1	455
		Industry|Other|NIH	1	8381
	Metastatic Breast Cancer	Industry	17	2042
		Industry|Other	2	122
		Other	7	650
		Other|Industry	11	848
	Gastric Cancer	Industry	5	1815
		Other	7	875
	Breast Neoplasms	Industry	8	2555
		Other	8	2559
		Other|Industry	3	170
		Other|U.S. Fed|Industry	1	22
	BREAST CANCER	Industry	40	11835
		Industry|NIH	1	0
		Industry|Other	5	12214
		NIH	3	292
		Other	48	23143
		Other|Industry	41	4331
		Other|NIH	29	1157
		Other|NIH|Industry	3	202